Current Research Projects

Click here for details of Dr Singh’s research interests

Dr Singh is a Clinical Associate Professor of Surgery and a Primary Supervisor for the University of Sydney Postgraduate Researchers (HDR/ Higher Degree by Research) in Surgery.

Prof Singh is currently supervising:

5 (Five)

Masters and Doctoral (PhD) candidates.

If you are considering a research degree in ENT (Otolaryngology, Head and Neck Surgery) through the University of Sydney, we recommend you contact us to meet with Prof Singh. The University of Sydney is Australia’s oldest and largest medical school. We have dedicated research funding available. You will be supported by the research facilities of The University of Sydney and the clinical resources of The Western Sydney LHD, including Westmead Hospital, Australia’s largest healthcare campus. Prof Singh has numerous research topics available for motivated researchers. Publication of your results is our priority.

Research focus areas

Prof Singh’s two key focus areas of research are:

  1. Computational Fluid Dynamics (CFD) in the nose and sinuses
  2. Artificial Intelligence (AI) in ENT

Please click on the pictures for an enlarged view

Clinical and Biomedical Engineering in the Human Nose

Current Research Projects

Click here to download a copy of Prof Singh's Thesis, for the award of Master of Surgery from The University of Sydney, entitled "Allergen Specific Cytokine Production by Cells Derived From Human Nasal Polyps"

Dr Singh's Thesis, for the award of Master of Surgery from The University of Sydney, entitled "Allergen Specific Cytokine Production by Cells Derived From Human Nasal Polyps

Click here to see Prof Singh's textbook, Clinical and Biomedical Engineering in the Human Nose

Recent Scientific publications

  1. Taylor A, Habib AR, Kumar A, Wong E, Hasan Z, Singh N. An artificial intelligence algorithm for the classification of sphenoid sinus pneumatisation on sinus computed tomography scans. Clin. Otolaryngol. (2023)
  2. Hasan Z, Key S, Lee M, Chen F, Aweidah L, Esmaili A, Sacks R, Singh N. A Deep Learning Algorithm to Identify Anatomical Landmarks on Computed Tomography of the Temporal Bone. J Int Adv Otol 2023; 19: 360-367.
  3. Khatri H, Salati H, Inthavong K, Singh N. Modelling the effects of post-FESS middle turbinate synechiae on sinonasal physiology: A computational fluid dynamics study. Auris Nasus Larynx.
  4. Habib AR, Xu Y, Bock K, Mohanty S, Sederholm T, Dodhia R, LavistaFerres J, Weeks WB, Perry C, Sacks R, Singh N, Evaluating the generalizability of deep learning image classification algorithms to detect middle ear disease using otoscopy. Nature Scientific Reports.
  5. Pezato R, Stamm AC, Douglas R, Han JK, Chen PG, Neto CDP, Tepedino MS, Singh N, Balsalobre L, ... Patel Z, Thamboo A. Nasal disease with polyps: Need for clarity. Int Forum Allergy Rh (2023).
  6. Habib AR, Perry C, Crossland G, Patel H, Kong K, Whitfield B, North H, Walton J, Da Cruz M, Suruliraj A, Smith M, Harris R, Hasan Z, Gunaratne DA, Sacks R, Singh N. Inter-rater agreement between 13 otolaryngologists to diagnose otitis media in aboriginal and Torres Strait islander children using a telehealth approach. International Journal of Pediatric Otorhinolaryngology, 2023,
  7. Fokkens W, Trigg A, Stella E, Chan R, Diamant Z, Hopkins C, Howarth P, Lund, V, Mayer B, Sousa A, Yancey S, Tabberer M, SYNAPSE study investigators(Includes Singh N). Mepolizumab improvements in health-related quality of life and disease symptoms in a patient population with very severe chronic rhinosinusitis with nasal polyps: psychometric and efficacy analyses from the SYNAPSE study. J. Patient-Rep. Outcomes 7, 4 (2023).
  8. Hasan Z, Lee M, Chen F, Key S, Habib AR, Aweidah L, Sacks R, Singh N. A computer vision algorithm to classify pneumatization of the mastoid process on temporal bone CT scans. J Int Adv Otol. 2023; 19(3):217-222.
  9. Kleven M, Singh N, Messina JC, Djupesland PG, Inthavong K. Development of computational fluid dynamics methodology for characterization of exhalation delivery system performance in a nasal airway with Draf-III surgery. Journal of Aerosol Science. 2022, 106121, ISSN 0021-8502,
  10. Senanayake P, Warfield-McAlpine P, Salati H, Bradshaw K, Wong E, Inthavong K, Singh N. The Impact of Adhesions on Nasal Airflow: A Quantitative Analysis Using Computational Fluid Dynamics. American Journal of Rhinology & Allergy. 2022;0(0).
  11. Bradshaw, K, McAlpine, P, Vahaji, S, Emmerling, J, Salati, H, Sacks, R, Fletcher, DF, Singh, N, Inthavong, K. New insights into the breathing physiology from transient respiratory nasal simulation. Phys Fluids 34, 115103 (2022).
  12. Vara Almirall B, Inthavong K, Bradshaw K, Singh N, Johnson A, Storey P, Salati H. Flow Patterns and Particle Residence Times in the Oral Cavity during Inhaled Drug Delivery. Pharmaceuticals. 2022; 15(10):1259.
  13. Tjahjono, R., Salati, H., Inthavong, K. &Singh, N. Correlation of Nasal Mucosal Temperature and Nasal Patency—A Computational Fluid Dynamics Study. Laryngoscope (2022)
  14. Salati H, Singh N, Khamooshi M, Vahaji S, Fletcher DF, Inthavong K. Nasal Irrigation Delivery in Three Post-FESS Models From a Squeeze-bottle Using CFD. Pharmaceut Res 1–16 (2022).
  15. Khatri H, Wong E, Inthavong K, Sacks R, Singh N. Peri-operative measures to prevent middle turbinate lateralisation and adhesion formation in endoscopic sinus surgery—a systematic review of the literature. Aust J Otolaryngol2022;5:20.
  16. Senanayake P, Wong E, McBride K, Singh N. Efficacy of Vidian Neurectomy and Posterior Nasal Neurectomy in the Management of Nonallergic Rhinitis: A Systematic Review. American Journal of Rhinology & Allergy 2022
  17. Habib A, Kajbafzadeh M, Hasan Z, Wong E, Gunasekera H, Perry C, Sacks R, Kumar A, Singh N. Artificial intelligence to classify ear disease from otoscopy: A systematic review and meta‐ Clin Otolaryngol (2022)
  18. Hasan Z, Key S, Habib A, Wong E, Aweidah L, Kumar A, Sacks R, Singh N. Convolutional Neural Networks in ENT Radiology: Systematic Review of the Literature. Annals of Otology, Rhinology & Laryngology 2022
  19. Habib A, Crossland G, Patel H, Wong E, Kong K, Gunasekera H, Richards B, Caffery L, Perry C, Sacks R, Kumar A, Singh N. An Artificial Intelligence Computer-vision Algorithm to Triage Otoscopic Images From Australian Aboriginal and Torres Strait Islander Children, Otology & Neurotology: April 2022 - Volume 43 - Issue 4 - p 481-488,
  20. Javadiyan S, Germein KC, Cooksley CM, Ramezanpour M, Singh N, Wormald PJ, Vreugde S, Psaltis AJ. In vitro safety and anti-bacterial efficacy assessment of acriflavine. Allergy 2022.
  21. Bhatia D, Bhatia K, Saluja T, Saluja A, Thind A, Bamra A, Singh G, Singh N, Clezy K, Dempsey K, Hudson B, Jain S. Under-mask beard covers achieve an adequate seal with tight-fitting disposable respirators using quantitative fit testing. J Hosp Infect (2022)
  22. Taylor A, North H, Singh N, Fagan P. From wipeout to drill out: a history of exostosis management and Australian surfing. Medical Journal of Australia 2022
  23. Tjahjono R &Singh N. Correlation between nasal mucosal temperature change and the perception of nasal patency: a literature review. J Laryngology Otology 135, 104–109 (2021).
  24. Shrestha K, Van Strien J, Shang Y, Fletcher DF, Petersen P, Vreugde S, Wormald PJ, Singh N, Inthavong K. Effect of breathing profiles on nebuliser drug delivery targeting the paranasal sinuses in a post-operative nasal cavity. J Aerosol Sci 105913 (2021)
  25. Bigdeli R, Jabbour J, Noor A, Bradshaw K, North H, Singh N, Sritharan N. Cotton bud foreign body associated necrotising otitis externa – A case series and literature review. Otolaryngology Case Reports 23, 100418 (2022).
  26. Inthavong, K, Shang Y, DelGaudio JM, Wise SK, Edwards TS, Bradshaw K, Wong E, Smith M, Singh N. Inhalation and deposition of spherical and pollen particles after middle turbinate resection in a human nasal cavity. RespPhysiolNeurobi 103769 (2021)
  27. Vahaji S, Shang Y, Zhang Y, Wong E, Rezk A, Yeo L, Vreugde S, Wormald PJ, Singh N, Inthavong K. Optimising Aerosol Delivery for Maxillary Sinus Deposition in a Post-FESS Sinonasal Cavities. Aerosol and Air Quality Research 21: 210098.
  28. Shrestha, K., Salati, H., Fletcher, D., Singh, N. & Inthavong, K. Effects of head tilt on squeeze-bottle nasal irrigation - a computational fluid dynamics study. J Biomech 110490 (2021)
  1. Singh, NP; Inthavong, K Can computational fluid dynamic models help us in the treatment of chronic rhinosinusitis?, Current Opinion in Otolaryngology & Head and Neck Surgery: February 2021 - Volume 29 - Issue 1 - p 21-26.
  2. Shrestha K, Wong E, Salati H, Fletcher DF, Singh N, Inthavong K. Liquid volume and squeeze force effects on nasal irrigation using Volume of Fluid modelling Experimental and Computational Multiphase Flow 2021
  3. Strien, JV, Shrestha K, Gabriel S, Lappas P, Fletcher DF, Singh N, Inthavong K. Pressure distribution and flow dynamics in a nasal airway using a scale resolving simulation. Phys Fluids 33, 011907 (2021).
  4. Shute, W. G., Wong, E. H., Agar, N. J. M. &Singh, N. Unilateral choanal atresia first diagnosed in adulthood and repaired via endoscopic posterior septectomy—a case series and review of the literature. Australian J Otolaryngology4, 2–2 (2021).
  5. Senanayake, P, Salati H, Wong E, Bradshaw K, Shang Y, Singh N, Inthavong K. The impact of nasal adhesions on airflow and mucosal cooling – A computational fluid dynamics analysis. RespPhysiolNeurobi 293, 103719 (2021).
  6. Shang Y, Inthavong K, Qiu D, Singh N, He F, Tu J (2021) Prediction of nasal spray drug absorption influenced by mucociliary clearance. PLoS ONE 16(1): e0246007.
  7. Han JK, Bachert C, Fokkens W, Desrosiers M, Wagenmann M, Lee SE, Smith SG, Martin N, Mayer B, Yancey SW, Sousa AR, Chan R, Hopkins C; SYNAPSE study investigators(Includes Singh N). Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med. 2021 Apr 16:S2213-2600(21)00097-7.
  8. Ahmadzada, S., Vasan, K., Sritharan, N., Singh, N., Smith, M., Hull, I., Riffat, F. (2020). Utility of narrowband imaging in the diagnosis of laryngeal leukoplakia: Systematic review and meta‐analysis Head & Neck.
  9. Wong E, Cheng AT, Aggarwala S, Cope D, Jessica N, Duvnjak M, Singh N. Acute food bolus ingestion: ten-year experience at a tertiary pediatric hospital. Australian J Otolaryngology3, 1–1 (2020).
  10. Shrestha K, Van Strien J, Singh N, Inthavong K (2020) Primary break-up and atomization characteristics of a nasal spray. PLoS ONE 15(8): e0236063.
  11. Wong E H, Noussair M, Hasan Z, Duvnjak M, Singh N. Physiological changes in the size of the septal swell body correlate with changes in inferior turbinate size. The Journal of Laryngology & Otology 2020
  12. Taylor, A., Vasan, K., Wong, E., Singh, N., Smith, M., Riffat, F., Sritharan, N. (2020). Black Turbinate sign: MRI finding in acute invasive fungal sinusitis. Otolaryngology Case Reports
  13. Parmar, P, A R Habib, D Mendis, A Daniel, M Duvnjak, J Ho, M Smith, D Roshan, E Wong, Singh N. 2020. An Artificial Intelligence Algorithm That Identifies Middle Turbinate Pneumatisation (Concha Bullosa) on Sinus Computed Tomography Scans. The Journal of Laryngology and Otology, 1–4.
  14. Ahmadzada, S., Tseros, E., Sritharan, N., Singh, N., Smith, M., Palme, C., Riffat, F. (2020). The value of narrowband imaging using the Ni classification in the diagnosis of laryngeal cancer Laryngoscope Investigative Otolaryngology
  15. Ho, J., Rom, D., Wong, E., Singh, N. (2020). A case of acute unilateral maxillary atelectasis following endoscopic pituitary surgery. International Journal of Surgery Case Reports
  16. Wong E, Deboever N, Sritharan N, Singh N. 2020. Laryngopharyngeal Reflux is Associated with Nasal Septal Deviation. (Eur J Rhinol Allergy 2020; 3: 1-3).
  17. Ho J, Wong E, Singh N. 2020 Bilateral Chronic Maxillary Atelectasis with a Unilateral Accessory Ostium. Eur J Rhinol Allergy 2020; 3(1): 23-5.
  18. Habib, A R, E Wong, R Sacks, Singh N. 2020. Artificial Intelligence to Detect Tympanic Membrane Perforations. The Journal of Laryngology and Otology, 1–5.
  19. Wong, E, Singh N. 2020. Isolated Sphenoid Allergic Fungal Sinusitis Causing Bilateral Blindness. Otolaryngology Case Reports, 100153.
  20. Wong, E, Deboever N, Chong J, Sritharan N, Singh N. 2020. Isolated Topical Decongestion of the Nasal Septum and Swell Body Is Effective in Improving Nasal Airflow. American Journal of Rhinology & Allergy,
  21. Smith, M, Wong E, Ho J, Tjahjono R, Coleman H, Singh N, Sritharan N. 2020. Ectopic Sinonasal Craniopharyngioma Arising From the Anterior Ethmoid Sinus – Case Report and Literature Review. Otolaryngology Case Reports 15: 100151.
  22. Inthavong K, Shang Y, Wong E, Singh N. Characterization of nasal irrigation flow from a squeeze bottle using computational fluid dynamics. Int Forum Allergy Rhinol. 2019 Nov 6.
  23. Singhal, P., Singh, N., Samra, S., Coleman, H. (2020). Olfactory neuroblastoma with divergent differentiation Pathology 52(), S86-S87.
  24. Inthavong, K., Das, P., Singh, N., &Sznitman, J. (2019). In silico approaches to respiratory nasal flows: A review. Journal of Biomechanics, 97, 109434.
  25. Wong, E., Inthavong, K., &Singh, N. (2019). Comment on the European position paper on diagnostic tools in rhinology - computational fluid dynamics. Rhinology, 0(0), 0–0.
  26. Huang, R., Nedanoski, A., Fletcher, D. F., Singh, N., Schmid, J., Young, P. M., et al. (2019). An automated segmentation framework for nasal computational fluid dynamics analysis in computed tomography. Computers in Biology and Medicine,115,103505.
  27. Huang, J, A R Habib, D Mendis, J Chong, M Smith, M Duvnjak, C Chiu, Singh N, E Wong. 2019. An Artificial Intelligence Algorithm That Differentiates Anterior Ethmoidal Artery Location on Sinus Computed Tomography Scans. The Journal of Laryngology and Otology, 1–4.
  28. Smith, M., Wong, E., Ahmadi, N., Singh, N. (2019). A nose out of joint: first reported case of prison-acquired marijuana-based rhinolith. BMJ Case Reports, 12, e231989.
  29. Ku D, Vasan K, Wong E, Tseros E, Singh N. Moffett's Solution Causes Significantly Greater Postoperative Throat Pain Compared to Cophenylcaine in Sinonasal Surgery. International Journal of Otolaryngology. July 2019.
  30. Andrews D, Wong EH, Ho J, Singh N. Chondro-Osseous Respiratory Epithelial Adenomatoid Hamartoma (COREAH): Case Report and Literature Review. Case Reports in Otolaryngology. July 2019.
  31. Wong EH, Choroomi S, Palme CE, Singh N. Isolated primary maxillary sinus esthesioneuroblastoma presenting as idiopathic syndrome of inappropriate antidiuretic hormone. BMJ Case Reports. May 2019.
  32. Wong EH, Cheng AT, Aggarwala S, Chong J, Duvnjak M, Azimi F, Cope D, Singh N. Paediatric fish bone ingestion: a 10-year analysis at a tertiary pediatric hospital. Australian Journal of Otolaryngology. May 2019. 2:16-16.
  33. Wong EH, Al-Eitri A, Chong J, Brown SJ, Dexter MAJ, Singh N. An alternative technique for pituitary tumour removal: Sequential endoscopic-microscopic pituitary procedure (SEMPP). Journal of Clinical Neuroscience. 64, 94-97. April 2019.
  34. Karunaratne Y, Gunaratne DA, Floros P, Wong EH, Singh N. Frontal Sinus Osteoma: From Direct Excision to Endoscopic Removal. The Journal of craniofacial surgery. April 2019 .
  35. Ansari UH, Wong EH, Smith M, Singh N, Palme CE, Smith M, Riffat F. Validity of narrow band imaging in the detection of oral and oropharyngeal malignant lesions: A systematic review and meta-analysis. Head & Neck 41(7). March 2019.
  36. Ho J, Wong E, Tseros E, Gunaratne D, Singh N. Chronic maxillary atelectasis (including silent sinus syndrome) can present bilaterally. JLO. Feb 2019.
  37. Singh N, Chong J, Ho J, Jayachandra S, Cope D, Azimi F, Eslick G, Wong E. Predictive Factors Associated With Spontaneous Passage Of Coins: A Ten-Year Analysis Of Paediatric Coin Ingestion In Australia. Int J PaedOtolaryngol. 2018 Oct;113:266-271.
  38. Singh N, Wong E, Huang J, Riffat F. Trans-Frontal Five-Fluorouracil: A novel technique for the application of adjuvant topical chemotherapeutic agents in sinonasal adenocarcinoma. BMJ Case Reports. October, 2018.
  39. Sekhar V, Wong E, Elhassan H, Singh N. Moffett's muted mules: The science of laryngology in the art of war. JLO. 2018; October.
  40. Burgos Olmos M, Sanmiguel-Rojas E, Singh N, Esteban-Ortega F. DigBody®: a new 3D modeling tool for nasal virtual surgery. Comput Biol Med. 2018. 98, 118-125.
  41. Ho J, North H, Singh N. 40 Years of ‘Waltzing Matilda’: The history of the multichannel cochlear implant. Med J Aust. Dec 2018.
  42. Wong E, Singh N. An improved method for temporary suture medialisation of the middle turbinates following endoscopic sinus surgery. Int J Otolaryngol. 2018 Sep 2;2018:9093545.
  1. Lau J, Elhassan H, Singh N. History of Intranasal Splints. JLO. 2018 Mar;132(3):198-201.
  1. Tseros E, Riffat F, Palme C, Coleman H, Singh N. Neville Wran’s Voice: How the NSW Premier’s teflon-coated vocal cords came unstuck. Med J Aust 2017; 207 (11): 468-470.
  2. Gunaratne, D., Hasan, Z., Floros, P., Singh, N. Bilateral stage I chronic maxillary atelectasis. Int J Surg Case Rep. 2016, 26, 53-56.
  1. Gunaratne D, Singh N. Endoscopic pedicled nasoseptal flap repair of spontaneous sphenoid sinus cerebrospinal fluid leaks. BMJ Case Rep  2015, 1-4.
  2. Morris C, Ng T, Kevin P, Singh N. IgG4-related disease isolated to the nasal cavity: a rare cause of nasal obstruction. Journal of Laryngology and Otology. 2015 Jan; 129: S57-59.
  3. Singh N, Roberts D. An Inexpensive Blue Filter for Fluorescein-Assisted Repair of Cerebrospinal Fluid Rhinorrhea. Laryngoscope. 2014 May; 124(5): 1103-5.
  4. Singh N, Walker RJ, Cowan F, Davidson C, Roberts D. Retrograde air escape via the nasolacrimal system: A previously unrecognised complication of continuous positive airway pressure in the management of obstructive sleep apnea. Ann OtolRhinolLaryngol. 2014 May; 123(5): 321-4.
  5. Faith, A*., Singh, N*., Farooque, S., Dimeloe, S., Richards, D., Lu, H., Roberts, D., Chevretton, E., Lee, T., Corrigan, C., Hawrylowicz, C. (2012), T cells producing the anti-inflammatory cytokine IL-10 regulate allergen-specific Th2 responses in human airways. Allergy. 67(8), 1007-1013. *Note: NS and AF contributed equally to the work (see publication manuscript)
  6. Singh N, Faith A, Hawrylowicz C, Roberts DN, Corrigan CJ. Allergen-Specific Cytokine Production by Human Nasal Polyps. Otolaryngology--Head and Neck Surgery 145 (2 suppl), P116-P116.
  7. Greaney L, Singh N, Roberts DN. Surgical Management of Rhinophyma. Clinical Otolaryngology (2010), 35, 147–163.
  8. Faith, A., Singh, N., Chevretton, E., Roberts, D., Lee, T., Corrigan, C., Hawrylowicz, C. (2009), Counter regulation of the high affinity IgE receptor, FcepsilonRI, on human airway dendritic cells by IL-4 and IL-10. Allergy. 64(11), 1602-1607.
  9. Singh N, Rizk JG. Oesophageal perforation following the ingestion of over-the-counter ibuprofen capsules. Journal of Laryngology and Otology (2008), 122, 864–866.
  10. Singh N, Fung A, Cole IE. Innominate artery haemorrhage following tracheostomy. Otolaryngology, Head and Neck Surgery (2007) 136, S68-S72.

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